Refines wet milling with clean and sterile technology

The DYNO^®-MILL MULTI LAB CIP/SIP from WAB-GROUP^® is a specially designed agitator wet mill for sterile research and development, pilot, and production operations in the pharma industry. It can process low to high-viscous products with batch sizes starting from 500 ml. What is more, it comes with easily interchangeable grinding chambers from 0.3 l to 1.4 l. It can accommodate both, WAB KD agitator discs as well as the DYNO^®-ACCELERATOR. The use of agitating small beads in wet milling efficiently grinds suspended particles to the low micrometer or even nanometer range, maintaining a narrow particle size distribution.

Cleaning in Place (CIP) ensures there is no direct contact between the plant operator and active pharmaceutical ingredients. Steam sterilization up to 135°C ensures plant sterility, guaranteeing a germ-free production of tablets, capsules, injectables, and vaccines.

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Achieves perfect homogenization of APIs with three-dimensional mixing

TURBULA^®, a 3D shaker mixer from WAB-GROUP^®, is designed for uniformly mixing powdery substances with diverse particle sizes and specific weights. It excels in handling both wet and dry components, like powder inhalers or API.  Based on the Schatz geometric theory, its distinctive three-dimensional motion incorporates rotation, translation, and inversion. It facilitates a dynamic and harmonious mixing of the API with the carrier material. This constant, rhythmic pulsing motion of the shaker container ensures exposure to a vibrant, homogeneous mixing. Available in a range of configurations to accommodate container volumes spanning from 0.1 to 55 liters, the 3D shaker mixer proves its versatility across various pharma industries, R&D labs, as well as pharma production plants.

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Employs ultra-fine grinding for cell disruption and extraction of ingredients

DYNO^®-MILL MULTI LAB (ML) from WAB-GROUP^® is an adaptable laboratory agitator bead mill, well-suited for small-scale productions and R&D in biotechnology. Suitable in continuous and discontinuous operations, the bead mill specifically designed for smaller applications can utilize ultra-fine grinding beads as small as 0.1mm. It has adjustable grinding chamber sizes, material selection, and adaptable grinding technology. It incorporates two grinding principles in one mill: the DYNO^® agitator disc and the patented DYNO^®-ACCELERATOR.

Discontinuous operation utilizes grinding vessels of 0.15 l and 0.3 l to handle low-viscosity suspensions. The batches range from 85 ml to 170 ml. Continuous operation is suitable for processing highly fluid to viscous, pumpable products.  It employs grinding containers of 0.15, 0.3, 0.6, and 1.4 l to process batch sizes exceeding 500 ml. Using superior ceramic components such as SiC and ZrO₂ ensures no metal contamination and an extended service life.

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Lifts and Maneuvers Containers Safely

The Hanningfield Uni-Hoist series, including models like the HEM and HES, represents a versatile range of industrial hoists designed for precise container handling. These hoists excel with their stainless steel construction, ensuring durability and compliance with hygienic GMP environments. The Uni-Hoist systems efficiently lift, rotate, and dock containers such as IBCs and drums, reducing manual labor and enhancing safety in pharmaceutical, nutraceutical, and chemical processing.

With a choice between electric, pneumatic, and manual operations, these systems integrate seamlessly into production lines, offering flexibility for stationary and mobile setups. Their lifting capacity ranges from medium duty (SWL ≤ 750 kg) to heavy duty (SWL ≤ 2000 kg), suitable for varied industrial applications. Incorporating fail-safe mechanisms, these hoists prevent load slippage, ensuring reliable operation.

Customizable options include different arm attachments and power configurations, with ATEX versions available for explosive environments. The Uni-Hoist series also supports full validation documentation, making it an asset for industries demanding strict compliance and operational efficiency.

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Processes and Sterilizes Liquid Parenteral Pharmaceuticals

The SVP Essential and LVP systems from Syntegon provide modular solutions tailored for liquid pharmaceutical manufacturing. Designed for flexibility, these systems handle mixing, homogenizing, and filling of both small and large volume parenterals. With capacities ranging from 13 to 20,000 liters, they integrate seamlessly into production lines through automation, enabling efficient batch and continuous operations. These systems feature robust CIP/SIP capabilities, ensuring rapid, contamination-free cleaning. Constructed with stainless steel, they comply with GMP and FDA standards, making them ideal for antibiotics, infusion solutions, and cell culture media production. The prefabricated cleanroom design reduces installation time and guarantees a minimal footprint, adapting to various production requirements. With over 70 pre-tested modules and ISA-88 structured automation, Syntegon’s solutions ensure process precision and operational control.

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Fills and Seals Vials for Liquid Pharmaceuticals

The FLC 3000 from Syntegon is designed to efficiently fill and seal vials in liquid pharmaceutical production lines, particularly for high-demand products like Covid-19 vaccines and monoclonal antibodies. Its compact GMP-compliant design supports a wide filling range of 0.2 to 500 milliliters and achieves throughput of up to 600 vials per minute, reducing changeover times with only three format part sets required. The machine’s peristaltic pump technology ensures precise dosing while maintaining sterility, and it integrates seamlessly into production environments with options for full in-process control. A clean and hygienic design facilitates easy maintenance and operator safety, meeting stringent GMP and FDA requirements. The FLC 3000 can be customized with additional filling technologies and systems as needed, providing robust support for both batch and continuous operations.

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DO2 Sensor optimized for bioprocesses

The Dissolved Oxygen sensor is a measuring device that informs about the dissolved oxygen in biotechnology processes, which is a basis for process optimization and control.

The AppliSens Low-Drift DO2 sensor from Getinge Applikon is specifically designed for long-term, stable, and accurate measurements in bioprocesses, such as fermentation and cell culture applications. Designed to withstand repeated sterilizations without failure.

The DO2 sensor has a titanium membrane module to minimize the measurement drift, and the available autoclave polarization module allows you to reduce start-up time for your cultures.

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Cultivation in microtiter plates

The Micro-Flask system by Getinge Applikon, is a simple and powerful set of tools for improving the quality of experiments performed in micro-titer plates. Using a unique “sandwich cover” plate closure, it is possible to eliminate well-to-well variability in flasks, dramatically improve gas transfer in cultures, and achieve outstanding results from high-throughput experimentation.

The Micro bioreactor ensures that every microtiter plate is exposed to identical culture conditions. In addition to preventing cross-contamination during vigorous shaking, the sandwich covers also provide uniform diffusion paths for each well, virtually eliminating well-to-well variability.

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Rocking Single-Use Bioreactors from 10 up to 50 liter volume

The Single-use bioreactor Appliflex, from Getinge Applikon is a flexible bag bioreactor ideal for cell culture, specially the growth of animal cells like CHO cells, Hybridoma cell lines and insect cells like Sf-9, Sf-21 cells, also excellent working for the seeding of pre-seeding for larger cell cultivation systems.

Offering reliable measurement and control in rocking Single-Use Bioreactors from 10 up to 50-liter volume. The bag and sensors (pH, dissolved oxygen, T) are designed for single-use, in compliance with CE guidelines.

The control system (pH, DO, T, rpm) is formed by the standard Getinge Applikon ez-Control, which guarantees real-time measurement of pH, DO, T and rocking speed.

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