Shreds and Reduces Size of Bulk Materials

The Hanningfield Pharmaceutical Shredder is a purpose-built solution for achieving efficient pre-milling size reduction of bulk materials such as pharmaceutical powders and nutraceutical granules. This shredder stands out with its compact design, suitable for inline integration within continuous processing operations. The unit operates by rapidly shredding and reducing the size of agglomerated powders and granules, using rotational speeds of 1,000-2,000 RPM for effective grinding.

Ideal for applications in pharmaceuticals, nutraceuticals, fine chemicals, and cannabis industries, it supports the production of tablets, capsules, dietary supplements, and herbal extracts by preparing materials for subsequent milling processes. Its high throughput capacity ensures maximum productivity, seamlessly integrating with upstream and downstream equipment via tri-clover connections.

Constructed with FDA-compliant 316L stainless steel contact parts for superior corrosion resistance, the shredder complies with GMP standards. The equipment offers a clean, GMP design with easy maintenance and is customizable with various sizes to meet specific throughput requirements. Hanningfield provides full engineering support, ensuring each machine aligns with your operational needs, complete with detailed validation documentation and certifications for compliance.

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Breaks and Size-Reduces Agglomerated Materials

The Hanningfield Pre-Breakers, available in models ND150, ND200, and ND300, are engineered to effectively break down and size-reduce agglomerated materials across industries such as pharmaceutical, food and beverage, and chemical. Utilizing a high-speed attrition mechanism, this equipment ensures quick processing with reduced manual intervention and facilitates seamless integration with existing processing lines through Tri-Clover connections. Capable of handling a wide range of materials including pharmaceutical powders, protein supplements, and herbal tea blends, these Pre-Breakers operate at rotational speeds up to 1800 RPM, providing flexible throughput configurations.

Constructed from 316L stainless steel with FDA-compliant parts, they offer excellent corrosion resistance and are designed to meet GMP and ATEX standards, ensuring safety and regulatory compliance. The easy-clean design allows for complete disassembly without tools, contributing to efficient maintenance and hygienic operations. Customizable options, including various inlet/outlet sizes and material upgrades, are available to align precisely with your application needs, supported by full validation documentation for smooth implementation and compliance assurance.

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Mixes and Granulates Pharmaceutical Powders

The high-shear mixer granulator from Syntegon, featuring the innovative Hüttlin Gentlewing impeller, is specifically designed for pharmaceutical and nutraceutical production lines. It excels in mixing and granulating powders into uniform granules, crucial for oral solid dosage forms like tablets and capsules. Its unique impeller design ensures superior mixing and reduced wall caking, enhancing yield and process reliability. You can achieve granulation of challenging products like high-potent APIs and effervescent tablets, with batch capacities ranging up to 1,800 liters. Automation is seamless with its PLC-controlled system, supporting remote operation and integration into existing lines.

Offering energy efficiency through optimized motor control, this equipment minimizes solvent use and pollution. Available in top or bottom drive configurations, it features a purged sealing system to prevent cross-contamination, and is constructed from corrosion-resistant materials suitable for GMP environments. Maintenance is straightforward with integrated CIP systems, ensuring rapid cleaning cycles. Customization options like variable impeller designs and containment upgrades are available to meet specific production needs.

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Enables Precise Dosing and Continuous Production

The Xelum Continuous Manufacturing Platform from Syntegon is a transformative solution for the pharmaceutical and nutraceutical industries, offering seamless integration of precise dosing and continuous production for oral solid dosage forms. By leveraging discrete mass dosing, the Xelum platform eliminates the need for traditional scale-up, ensuring high content uniformity even for APIs below 1%. This system is ideal for producing a variety of products such as antibiotic tablets and antiviral capsules, thanks to its robust fluid bed processors that handle granulation and drying in a single chamber, avoiding wet granulate transfer and enhancing reliability. With throughput capacities ranging from 10 to 100 kg/h, Xelum supports rapid production cycles and maintains exact standards in API concentration.

The platform is fully automated, featuring PLC-controlled operations with direct process parameter transfers from R&D to production, allowing for efficient pilot and clinical trials without the constraints of scaling up. It accommodates complex formulations with contained capabilities for OEB4 materials and integrated WIP systems. Xelum’s design prioritizes energy efficiency, reducing production costs while maintaining flexibility for both tablets and capsules. Engineered to meet stringent GMP and FDA standards, it offers a clean-in-place (CIP) system ensuring fast, contamination-free cleaning, perfect for high-potent API development. Customization support allows for tailored configurations to suit specific manufacturing requirements, making Xelum a cornerstone for forward-looking production strategies.

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Fills and Seals Capsules with Precision

The GKF 702 from Syntegon offers a versatile solution tailored for R&D labs and small batch production, capable of handling up to 42,000 capsules per hour. This capsule filling machine excels in precise dosing of both HPMC and gelatin capsules with a modular design that facilitates quick changeovers between different product types, including powders, granules, and liquids. Utilizing a slide-gate technology, it ensures minimal product loss and maximized yields. Integrated with automated systems for dosing and weighing, it optimizes productivity in pharmaceutical, nutraceutical, and health product manufacturing. The machine’s design supports seamless integration into production lines with minimal operational downtime. With robust material options and compliance with industry standards, the GKF 702 ensures reliability and efficiency in diverse processing environments.

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Fills and Seals Capsules with Precision

The GKF Capsylon Series from Syntegon is an automated solution for precise capsule filling and sealing, tailored for the nutraceutical and pharmaceutical sectors. With a modular design, these machines adapt to fill a range of capsule types, from powders to granules, effectively reducing product waste and improving yield. Capable of producing up to 360,000 capsules per hour, the series is ideal for high-volume operations, including vitamins, probiotics, and herbal supplements. Integration into existing production lines is seamless, thanks to its PLC control and user-friendly interface. The machines are energy-efficient, featuring slide-gate technology that minimizes dust and product loss. Built from robust materials, they are compliant with GMP standards, ensuring quality and safety. Maintenance is streamlined through easy-to-clean components and optional CIP systems, while Syntegon offers extensive customization and support to meet diverse production needs.

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Fills and Packages Nutraceutical Capsules and Granules

Syntegon’s Nutraceutical Granule and Capsule Filling System offers a comprehensive solution tailored for the needs of nutraceutical producers and pharmaceutical manufacturers. Designed to improve operational efficiency, this system precisely fills capsules and packages granules, ensuring accurate dosage and minimal waste. Integrating seamlessly into both batch and continuous operations, it supports various production scales. The system accommodates a wide array of applications from encapsulating omega-3 capsules and vitamin tablets to packaging protein powder sachets and probiotic gummies.

With automation at its core, the system is equipped with PLC controls for streamlined operations and offers remote monitoring for enhanced production oversight. The equipment is constructed with durable stainless steel options, ensuring compliance with GMP standards and reliability under extensive operational use. Maintenance is efficient with an integrated CIP system that allows thorough cleaning without manual intervention. Additionally, customization options are available to adapt filling and packaging capabilities to specific product requirements, providing engineering support to optimize your production line.

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Fills, Seals, and Packs Diverse Products

The VFFS Packaging Machine from Syntegon revolutionizes packaging with its versatile design for both the food and pharmaceutical industries. It excels in filling, sealing, and packing various products such as bread rolls, cornflakes, and espresso pods. Utilizing continuous and high-speed operation, it seamlessly integrates into existing production lines, enhancing efficiency. The machine supports multiple bag styles, including Doy Zip and stick packs, and boasts an easy-to-use HMI for rapid changeovers and minimal downtime. Built with robust servo technology, it ensures energy efficiency and precision, helping manufacturers meet stringent hygiene and industry standards. Custom engineering options and maintenance services are available to match specific operational needs.

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Automates Product Handling and Packaging Processes

The Syntegon Robotic Pick and Place Platform (RPP) offers a game-changing solution for diverse industries seeking to advance their packaging operations. This modular platform excels in automating product handling and placement with precision and efficiency.

Using integrated delta robots, the RPP system provides seamless product loading into trays or cartons, capable of achieving up to 140 picks per minute per robot, optimizing high-speed environments. Its design supports applications across pharmaceuticals, bakery products, confectionery, dairy, and more, enhancing operations from ampoules to chocolate bars.

With its compact footprint, the RPP is PLC-controlled, supporting remote monitoring and smart interface integration for scalable capacity adjustments. Its construction in stainless steel offers superior hygienic operations and compliance with rigorous industry standards, including IP65 protection for wash-down scenarios. The platform’s vision-guided inspection technologies ensure tight quality control, identifying and removing any defective products in the process.

Syntegon’s RPP system includes quick-change end-of-arm tooling for format flexibility, supporting gentle and safe product handling while reducing contamination risks. It simplifies cleaning with its open-channel, self-draining design, paired with optional CIP systems. Custom configurations and engineering support are available to tailor the platform to your specific production demands, ensuring streamlined integration into existing production lines.

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Processes and Coats Pharmaceutical Powders and Tablets

The comprehensive range of equipment from Syntegon, including mixers, granulators, dryers, tablet presses, tablet coaters, and capsule fillers, is designed to enhance pharmaceutical production efficiency. These machines support various processes, such as mixing, granulating, drying, and tablet pressing, crucial for creating products like paracetamol powder, ibuprofen tablets, and vitamin D capsules. Operating under batch, pilot, or continuous modes, these systems are equipped with Automated Process Development (APD) capabilities for precision and optimization. The equipment offers high throughput and adaptability, tailored for pharmaceutical manufacturers and R&D labs. Constructed with corrosion-resistant materials, it meets GMP and FDA standards. Clean-in-place (CIP) systems are integrated for efficient maintenance, while customization options include process parameters and engineering support to suit specific production needs.

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