Refines wet milling with clean and sterile technology

The DYNO^®-MILL MULTI LAB CIP/SIP from WAB-GROUP^® is a specially designed agitator wet mill for sterile research and development, pilot, and production operations in the pharma industry. It can process low to high-viscous products with batch sizes starting from 500 ml. What is more, it comes with easily interchangeable grinding chambers from 0.3 l to 1.4 l. It can accommodate both, WAB KD agitator discs as well as the DYNO^®-ACCELERATOR. The use of agitating small beads in wet milling efficiently grinds suspended particles to the low micrometer or even nanometer range, maintaining a narrow particle size distribution.

Cleaning in Place (CIP) ensures there is no direct contact between the plant operator and active pharmaceutical ingredients. Steam sterilization up to 135°C ensures plant sterility, guaranteeing a germ-free production of tablets, capsules, injectables, and vaccines.

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Achieves perfect homogenization of APIs with three-dimensional mixing

TURBULA^®, a 3D shaker mixer from WAB-GROUP^®, is designed for uniformly mixing powdery substances with diverse particle sizes and specific weights. It excels in handling both wet and dry components, like powder inhalers or API.  Based on the Schatz geometric theory, its distinctive three-dimensional motion incorporates rotation, translation, and inversion. It facilitates a dynamic and harmonious mixing of the API with the carrier material. This constant, rhythmic pulsing motion of the shaker container ensures exposure to a vibrant, homogeneous mixing. Available in a range of configurations to accommodate container volumes spanning from 0.1 to 55 liters, the 3D shaker mixer proves its versatility across various pharma industries, R&D labs, as well as pharma production plants.

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Employs ultra-fine grinding for cell disruption and extraction of ingredients

DYNO^®-MILL MULTI LAB (ML) from WAB-GROUP^® is an adaptable laboratory agitator bead mill, well-suited for small-scale productions and R&D in biotechnology. Suitable in continuous and discontinuous operations, the bead mill specifically designed for smaller applications can utilize ultra-fine grinding beads as small as 0.1mm. It has adjustable grinding chamber sizes, material selection, and adaptable grinding technology. It incorporates two grinding principles in one mill: the DYNO^® agitator disc and the patented DYNO^®-ACCELERATOR.

Discontinuous operation utilizes grinding vessels of 0.15 l and 0.3 l to handle low-viscosity suspensions. The batches range from 85 ml to 170 ml. Continuous operation is suitable for processing highly fluid to viscous, pumpable products.  It employs grinding containers of 0.15, 0.3, 0.6, and 1.4 l to process batch sizes exceeding 500 ml. Using superior ceramic components such as SiC and ZrO₂ ensures no metal contamination and an extended service life.

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Controls and Transfers Powders Safely

The Sterisplit Split Butterfly Valve from Hanningfield offers a reliable solution for handling and transferring pharmaceutical, nutraceutical, and chemical powders. Designed to meet stringent cGMP and EHEDG standards, this valve features a unique two-part design, allowing for controlled powder flow while maintaining a clean external surface. Its stainless steel construction ensures durability and resistance to corrosion, while translucent silicone, EPDM, and FKM seals offer compatibility with various substances. Applications span paracetamol tablets, protein supplements, and even dangerous substances like pesticides and explosive powders. Integrating seamlessly into existing production lines, the Sterisplit supports both manual and continuous operations, ensuring precise dosing and efficient containment. With certifications such as FDA compliance and ATEX safety, and a CIP-ready design for easy cleaning, this valve is customizable to suit diverse industrial needs.

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Mixing and freeze-drying in one step

The active freeze dryer from Hosokawa Micron uses very low temperatures and a vacuum to dry your product and to obtain it in very good quality. Due to the low temperatures usage the damage of heat sensitive products, such as enzymes, flavors, proteins, vitamins and so on is avoided. Hand traditional tray-type freeze dryers are slow and labor-intensive. Hosokawa’s Active Freeze Dryer ® eliminates these drawbacks.
Typical applications include pharmaceuticals like antibiotics, collagens, APIs and electrolytes; Food industry and in special materials like nanomaterials, polymers, ceramics, pigments, fillers, limestone, catalysts, glass powder and salts.

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Ensures Sterility and Safe Aseptic Processing

The ISOPRIME Isolators from Getinge provide a robust solution for pharmaceutical, biotech, and healthcare facilities requiring stringent sterility and contamination control. Designed with modular rigid-wall systems, the ISOPRIME excels in a range of aseptic and sterile processing applications, including compounding, aseptic filling, and sterility testing. Engineered for continuous operation, these isolators incorporate a validated Siemens PLC for reliable process control and traceability while supporting large-scale production efficiency through versatile airflow options—unidirectional or turbulent.

Suited for a diverse array of end-products like monoclonal antibodies, saline IV bags, and personalized cancer vaccines, ISOPRIME ensures compliance with FDA 21 CFR Part 11. It delivers comprehensive bio-decontamination capabilities through an integrated H2O2 generator, facilitating in-situ cleanliness and safety.

Optimized for ease of access and maintenance, the design features upward-opening doors and convenient electrical cabinet entry points, reducing downtime. Integration with Getinge’s DPTE® transfer system guarantees secure material transfer without breaking containment, while glove leak testing technology ensures operational integrity.

Constructed for resilience, ISOPRIME offers various customization options, including specific ventilation and access configurations, tailored to meet unique production line needs. It supports both liquid and solid product types, making it adaptable across laboratories and processing departments dedicated to cutting-edge medical solutions.

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Enables Secure Aseptic Transfers and Material Handling

The DPTE® Transfer Trolley from Getinge is an ergonomic and power-assisted solution designed for aseptic material handling in pharmaceutical and biotechnology settings. This trolley is integral to ensuring sterile transfers of vaccines, injectable pharmaceuticals, and other biopharmaceutical products, using precision motors for fine-tuned positioning and programmable memory functions for quick alignment. With applications in pharma production and research labs, it supports both DPTE-BetaBag® and DPTE® Beta Container systems, accommodating various diameters for flexible usage. Its compact design includes a 24-hour battery autonomy, IP66 electrical compliance, and anti-static wheels for optimal maneuverability in confined spaces. The power-assisted controls reduce manual labor, enhancing production uptime and user safety. Configurable to user requirements, the trolley meets rigorous industry standards, ensuring it integrates seamlessly with existing aseptic transfer processes.

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Labels and Verifies Pharmaceutical Containers

The LR105 by CAM is a high-speed labelling solution specifically designed for the pharmaceutical industry. This automated machine excels in labelling vials, ampoules, carpules, and syringes at speeds of up to 500 labels per minute. Capable of both inkjet and thermal transfer printing, the LR105 integrates seamlessly into your production line, offering full control via an intuitive operator panel. Customizable options include checking systems for accurate printing verification, label code readers, and product rejection capabilities for quality assurance. Ideal for pharmaceutical manufacturers, the LR105 ensures compliance with stringent industry standards and provides reliable, precise labelling for a wide range of liquid pharmaceutical products, from insulin vials to chemotherapy drug ampoules.

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Performs Sterilization of Diverse Pharmaceutical Products

The SteriMega Plus from Telstar is a saturated steam sterilizer designed to handle a wide range of materials, including solid, porous, and liquid products, critical in pharmaceutical and biotech manufacturing. Its high-performance steam sterilization process conforms with GMP standards and European certifications like EN 285 and PED, ensuring regulatory compliance. With customizable options, this equipment offers versatility to address specific production needs, making it suitable for sterilizing ampoules, syringes, culture media, and more.

Incorporating advanced automation, the SteriMega Plus seamlessly integrates into existing production lines, offering PLC control for efficient operation. Its robust design supports batch, pilot, and continuous operations. Material options like stainless steel enhance durability and corrosion resistance. Equipped with a CIP (Clean-In-Place) system, it simplifies maintenance and ensures minimal downtime, solidifying its role as a reliable asset in ensuring sterility and product safety in critical production environments.

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Monitors Sublimation Front Advancement in Real-Time

The Telstar Sublime is a real-time sublimation front monitoring system designed for pharmaceutical and biotechnology industries. This innovative system employs single-use wireless probes to track the sublimation front temperature interface during freeze-drying. It excels in optimizing cycle development by providing accurate multipoint temperature readings, thus enhancing process understanding and repeatability. Key applications include the production of monoclonal antibodies, lyophilized vaccines, and vitamin tablets. The Sublime integrates seamlessly with automatic loading and unloading systems, reducing logistics complexity and cross-contamination risks. It is fully compliant with cGMP and FDA 21 CFR Part 11 standards, ensuring the highest level of quality control for your operations.

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