Processes and Coats Pharmaceutical Powders and Pellets

The Syntegon Fluid Bed Processor offers pharmaceutical and nutraceutical manufacturers an indispensable solution for drying, granulating, and coating operations. Utilizing the unique Hüttlin Diskjet air distribution system and bottom spray technology, it provides homogeneous mixing and faster drying, catering to tasks like producing paracetamol tablets and vitamin D capsules. With batch capacities ranging from bench-top R&D sizes up to 1,600 kg, it ensures high throughput and versatility across processes. The processor’s three-component nozzle system enhances spray rates and product yield, supporting integration into continuous production lines with ease. Automated features, such as dynamic filtering and cleaning-in-place (CIP) options, meet stringent GMP standards, aligning with energy-efficient practices that lower operational costs. Available in industrial-grade materials to ensure chemical compatibility, this equipment exemplifies precision, compliance, and adaptability.

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Enables Precise Dosing and Continuous Production

The Xelum Continuous Manufacturing Platform from Syntegon is a transformative solution for the pharmaceutical and nutraceutical industries, offering seamless integration of precise dosing and continuous production for oral solid dosage forms. By leveraging discrete mass dosing, the Xelum platform eliminates the need for traditional scale-up, ensuring high content uniformity even for APIs below 1%. This system is ideal for producing a variety of products such as antibiotic tablets and antiviral capsules, thanks to its robust fluid bed processors that handle granulation and drying in a single chamber, avoiding wet granulate transfer and enhancing reliability. With throughput capacities ranging from 10 to 100 kg/h, Xelum supports rapid production cycles and maintains exact standards in API concentration.

The platform is fully automated, featuring PLC-controlled operations with direct process parameter transfers from R&D to production, allowing for efficient pilot and clinical trials without the constraints of scaling up. It accommodates complex formulations with contained capabilities for OEB4 materials and integrated WIP systems. Xelum’s design prioritizes energy efficiency, reducing production costs while maintaining flexibility for both tablets and capsules. Engineered to meet stringent GMP and FDA standards, it offers a clean-in-place (CIP) system ensuring fast, contamination-free cleaning, perfect for high-potent API development. Customization support allows for tailored configurations to suit specific manufacturing requirements, making Xelum a cornerstone for forward-looking production strategies.

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Fills and Seals Capsules with Precision

The GKF 702 from Syntegon offers a versatile solution tailored for R&D labs and small batch production, capable of handling up to 42,000 capsules per hour. This capsule filling machine excels in precise dosing of both HPMC and gelatin capsules with a modular design that facilitates quick changeovers between different product types, including powders, granules, and liquids. Utilizing a slide-gate technology, it ensures minimal product loss and maximized yields. Integrated with automated systems for dosing and weighing, it optimizes productivity in pharmaceutical, nutraceutical, and health product manufacturing. The machine’s design supports seamless integration into production lines with minimal operational downtime. With robust material options and compliance with industry standards, the GKF 702 ensures reliability and efficiency in diverse processing environments.

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Fills and Seals Capsules with Precision

The GKF Capsylon Series from Syntegon is an automated solution for precise capsule filling and sealing, tailored for the nutraceutical and pharmaceutical sectors. With a modular design, these machines adapt to fill a range of capsule types, from powders to granules, effectively reducing product waste and improving yield. Capable of producing up to 360,000 capsules per hour, the series is ideal for high-volume operations, including vitamins, probiotics, and herbal supplements. Integration into existing production lines is seamless, thanks to its PLC control and user-friendly interface. The machines are energy-efficient, featuring slide-gate technology that minimizes dust and product loss. Built from robust materials, they are compliant with GMP standards, ensuring quality and safety. Maintenance is streamlined through easy-to-clean components and optional CIP systems, while Syntegon offers extensive customization and support to meet diverse production needs.

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Processes and Coats Pharmaceutical Powders and Tablets

The comprehensive range of equipment from Syntegon, including mixers, granulators, dryers, tablet presses, tablet coaters, and capsule fillers, is designed to enhance pharmaceutical production efficiency. These machines support various processes, such as mixing, granulating, drying, and tablet pressing, crucial for creating products like paracetamol powder, ibuprofen tablets, and vitamin D capsules. Operating under batch, pilot, or continuous modes, these systems are equipped with Automated Process Development (APD) capabilities for precision and optimization. The equipment offers high throughput and adaptability, tailored for pharmaceutical manufacturers and R&D labs. Constructed with corrosion-resistant materials, it meets GMP and FDA standards. Clean-in-place (CIP) systems are integrated for efficient maintenance, while customization options include process parameters and engineering support to suit specific production needs.

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Facilitates Complete Silo Unloading

The Hydrasweep from Morillon is a high-capacity hydraulic sweep auger designed to optimize the unloading of bulk materials stored in silos. Combining the innovative design of the Spirogyre sweep auger with a robust hydraulic motor, this equipment ensures efficient extraction of challenging products like soy seeds, wood pellets, and grains. Once gravity-based unloading concludes, the Hydrasweep activates its auger, completing the process through a 360° rotation within the silo, requiring no human intervention. It is ideal for agriculture and port storage industries, capable of handling up to 500 tonnes per hour, and suitable for silos spanning 27 to 60 meters in diameter. The fully automatic operation integrates seamlessly into existing systems, offering a safe and reliable solution resistant to product sliding or falling. Optional ATEX certification ensures safe operation in explosive atmospheres, while low maintenance requirements and built-in brushes enhance longevity and reliability.

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Meters and Feeds Bulk Solids Accurately

The Smart Flow Meter K-SFM from Coperion K-Tron is a specialized device designed for the gentle and precise metering of bulk solids. This innovative flow meter stands out for its unique design, featuring no moving parts, which ensures reduced maintenance requirements and gentle handling of materials such as powders, grains, and fibers. Utilizing patented Smart Force Transducer technology, the K-SFM provides accurate flow rate measurement through two measuring channels, making it ideal for applications in plastics, chemicals, food, and more.

The K-SFM is suitable for continuous and automatic operations, handling diverse end-products like polyethylene pellets, epoxy resins, and flour efficiently. With variants like the K-SFM-275-B and K-SFM-350-B, it offers flexibility in processing capacity, accommodating a range of materials from 0.2 mm to 10 mm in size. It supports integration within production lines for material flow control, ensuring seamless material management and quantitative bulk goods measurement.

Constructed with stainless steel, AISI 316L, the device boasts high corrosion resistance, making it robust for demanding industrial environments. It is available with hazardous location options, including ATEX and NEC, ensuring safety and compliance in a variety of settings. Compact and reliable, the K-SFM allows easy disassembly for maintenance and cleaning, promoting operational efficiency and productivity.

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Processes and Pelletizes Polymers and Pharmaceutical Materials

The Coperion Strand Pelletizer SP 500 HD is engineered for efficient production and precision in polymer and pharmaceutical pelletizing applications. This machine excels by converting various polymer melts into uniform pellets suitable for plastics, chemicals, food products, and pharmaceuticals. Its robust design supports a throughput range from 30 to 6,300 kg/h, making it adaptable from small-scale operations to large continuous production lines. The SP 500 HD operates with a combination of cooling, dewatering, pelletizing, and screening processes, ensuring consistency and quality in the output.

Equipped with a PLC-based control system, it seamlessly integrates with upstream and downstream equipment, enhancing productivity while reducing manual intervention. The machine is constructed with corrosion-resistant materials and meets FDA and GMP standards, especially beneficial for pharmaceutical applications. It supports semi-automatic and automatic operations with options for customization, allowing for adjustments to suit specific production requirements. Maintenance is simplified through an accessible design that permits easy cleaning and minimizes downtime. Whether you are producing biodegradable plastic pellets or pharmaceutical granules, the SP 500 HD stands out for its versatility and engineering excellence.

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Conveys Powders, Pellets, and Granules Efficiently

The Positive Displacement Vacuum Blower from Coperion K-Tron is engineered to enhance continuous pressure and vacuum conveying of pellets, powders, and granules across multiple industries, including plastics, chemicals, food, and more. This blower package operates with a robust positive displacement mechanism, ensuring dependable transport in high-speed processing environments. Tailored to your operation’s needs, it supports systems from 51 mm to 254 mm and can generate up to 474 mbar of vacuum pressure.

Constructed for reliability and integration, it features a heavy-duty blower base and a totally enclosed drive guard. The inclusion of an IEC or NEMA motor mount frame facilitates seamless integration into existing production lines. The blower is equipped to handle diverse materials such as polyethylene pellets, PET flakes, and superabsorbent polymer fibers efficiently.

What sets this blower apart is its energy-efficient design, utilizing vibration mounting pads and a chamber-absorptive discharge silencer for quieter, smoother operation. It meets OSHA and CE compliance standards, ensuring it is safe and reliable for industrial application. Additionally, with customizable configurations and engineering support available, it is adaptable to specific production demands, enhancing overall conveying efficiencies.

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